2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Losatuxizumab

Losatuxizumab  (Synonyms: ABT-806)

目录号: HY-P99715 纯度: 95.00%
COA

摩尔计算器

Losatuxizumab (ABT-806) 是一种抗 EGFR 单克隆抗体。Losatuxizumab 可结合 EGFR，EGFR 野生型 EC50 为 0.96 nM，EGFRC271A, C283A 为 0.09 nM，EGFRvIII 为 0.12 nM，EGFR1-501 为 0.66 nM。Losatuxizumab 可用于研究表达 EGFR 的癌症。

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Losatuxizumab Chemical Structure

Losatuxizumab Chemical Structure

CAS No. : 1801544-27-3

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规格 价格 是否有货 数量
1 mg ￥3000
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5 mg ￥7800
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Losatuxizumab 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody. Losatuxizumab binds to EGFR with EC50s of 0.96 nM for EGFR wild-type, 0.09 nM for EGFRC271A,C283A, 0.12 nM for EGFRvIII, 0.66 nM for EGFR1-501. Losatuxizumab can be used for research of EGFR-expressing cancers[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric; Humanized
体外研究
(In Vitro)

Losatuxizumab (0.001 nM-100 nM) 可与表达 EGFRvIII 的细胞系 U87MGde2-7 结合[1]。
Losatuxizumab 抑制 NR6 huEGFRC271A,C283A 细胞系中 EGF 介导的 EGFR 磷酸化，IC50 为 1.2 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Losatuxizumab 相关抗体:
体内研究
(In Vivo)

Lorigerlimab 在多种表达野生型 EGFR 的鳞状细胞癌异种移植模型中均具有抗肿瘤活性[1]。
Lorigerlimab (40 mg/kg, 腹腔注射) 显着抑制小鼠 U87MGde2-7 肿瘤的生长[1]。
Lorigerlimab (10 和 40 mg/kg，腹腔注射) 在 PDX GBM 模型 (SN0207 肿瘤) 中延长生存期并降低肿瘤中 pEGFR 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PDX GBM model (SN0207 tumor)[1]
Dosage: 40 mg/kg
Administration: i.p.
Result: Prolonged survival rate, and reduced levels of pEGFR in tumor.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Losatuxizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Losatuxizumab1801544-27-3ABT-806ABT806ABT 806EGFREpidermal growth factor receptorErbB-1HER1Cancersquamous cell carcinomaEGFRvIIIGBMInhibitorinhibitorinhibit

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