2. Cell Cycle/DNA Damage
  3. CDK
  4. LY3177833 monhydrate

LY3177833 (Example 4) monhydrate 是一种具有口服活性的 CDC7 和 pMCM2 的抑制剂，其 IC50 值分别为 3.3 nM 和 290 nM。LY3177833 monhydrate 是一种衰老诱导剂。

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LY3177833 monhydrate Chemical Structure

LY3177833 monhydrate Chemical Structure

CAS No. : 1627696-53-0

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规格 价格 是否有货
1 mg ￥440
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5 mg ￥1100
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LY3177833 monhydrate 的其他形式现货产品:

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Other Forms of LY3177833 monhydrate:

LY3177833 monhydrate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].

IC50 & Target[1]

Cdc7

3.3 nM (IC50)

pMCM2

290 nM (IC50)

体外研究
(In Vitro)

LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY3177833 monhydrate 相关抗体:

Western Blot Analysis[2]

Cell Line: Hep3B cells
Concentration: 10 μM
Incubation Time: 4 days
Result: Increased the expression of human SA-β-gal.
体内研究
(In Vivo)

LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
Dosage: 10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration: Oral gavage; twice a day for 2 weeks
Result: Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.
分子量

327.31

Formula

C16H14FN5O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

LY3177833 monhydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY3177833 monhydrate1627696-53-0CDKCyclin dependent kinasepMCM2Hep3SA-β-galSW620Inhibitorinhibitorinhibit

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LY3177833 monhydrate
目录号：
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