2. Academic Validation
  3. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

  • Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30. doi: 10.1016/s0960-894x(99)00250-4.
G W Muller 1,  R Chen,  S Y Huang,  L G Corral,  L M Wong,  R T Patterson,  Y Chen,  G Kaplan,  D I Stirling
Affiliations

Affiliation

  • 1 Celgene Corporation, Warren, NJ 07059, USA.
PMID: 10386948 DOI: 10.1016/s0960-894x(99)00250-4
Abstract

Thalidomide, (1), is a known inhibitor of TNF-alpha release in LPS stimulated human PBMC. Herein we describe the TNF-alpha inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-alpha release in LPS stimulated human PBMC.

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