2. Academic Validation
  3. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro

Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro

  • Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. doi: 10.1128/AAC.34.2.373.
J F Manischewitz 1,  G V Quinnan Jr,  H C Lane,  A E Wittek
Affiliations

Affiliation

  • 1 Laboratory of Herpesvirus Research, Food and Drug Administration, Bethesda, Maryland 20892.
PMID: 2158278 DOI: 10.1128/AAC.34.2.373
Abstract

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus Infection while reducing drug toxicity.

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