1. Academic Validation
  2. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders

Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders

  • Biochim Biophys Acta. 2012 May;1822(5):748-52. doi: 10.1016/j.bbadis.2011.10.015.
Rukhsana Sultana 1
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. rsult@uky.edu
Abstract

Oxidative stress is involved in the onset, progression and pathogenesis of a number of diseases including neurodegenerative diseases. It is critical to develop a pharmacological approach to combat oxidative stress which may reduce the risk of diseases and help in promoting healthy life. In an attempt to reduce the side effects associated with allopathic medicines a number of studies are now focusing on developing treatment regimens from naturally occurring plant products. In this review, the protective role of ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA), a naturally occurring antioxidant compound found in fruit, some vegetables, and grains, and its ethyl ester derivative are discussed with respect to neurodegeneration. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease.

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