2. Academic Validation
  3. Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

  • Molecules. 2015 Aug 12;20(8):14565-75. doi: 10.3390/molecules200814565.
Xiang-Xi Yi 1,  Jia-Gang Deng 2,  Cheng-Hai Gao 3,  Xiao-Tao Hou 4,  Fei Li 5,  Zhi-Ping Wang 6,  Er-Wei Hao 7,  Yan Xie 8,  Zheng-Cai Du 9,  Hui-Xue Huang 10,  Ri-Ming Huang 11 12
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xiangxiyi81@aliyun.com.
  • 2 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. dengjg53@126.com.
  • 3 Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. gaochenghai@gxas.cn.
  • 4 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xthou@126.com.
  • 5 Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. finylee@yeah.net.
  • 6 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. wangzhiping@163.com.
  • 7 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. ewhao@163.com.
  • 8 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. xiey2009@126.com.
  • 9 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. duzhengcai8@163.com.
  • 10 School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. hhx123@hotmail.com.
  • 11 Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. huangriming@scib.ac.cn.
  • 12 Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. huangriming@scib.ac.cn.
PMID: 26274945 DOI: 10.3390/molecules200814565
Abstract

Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.

Keywords

Bruguiera gymnorrhiza; antiviral; cyclohexylideneacetonitrile derivative.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z