1. Academic Validation
  2. Carbidopa: a selective Ah receptor modulator (SAhRM)

Carbidopa: a selective Ah receptor modulator (SAhRM)

  • Biochem J. 2017 Nov 6;474(22):3763-3765. doi: 10.1042/BCJ20170728.
Stephen Safe 1
Affiliations

Affiliation

  • 1 Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, U.S.A. ssafe@cvm.tamu.edu.
Abstract

The Aryl Hydrocarbon Receptor (AhR) was discovered as the intracellular receptor that bound with high affinity to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the AhR is required for mediating the toxicity induced by TCDD. Subsequent studies show that the AhR binds structurally diverse chemicals including plant-derived compounds that promote health and several AhR-active pharmaceuticals that exhibit Anticancer activity. In this issue, there is a report that carbidopa, a drug used for treating Parkinson's disease, is also an AhR ligand, and this compound inhibits pancreatic Cancer cell and tumor growth. These results are consistent with activities of other AhR-active compounds that inhibit carcinogenesis. Like carbidopa, these chemicals are selective AhR modulators with potential clinical applications that are AhR-dependent.

Keywords

AhR; SAhRM; carbidopa; inhibition; pancreatic cancer.

Figures
Products