2. Academic Validation
  3. Anticancer Effects of Five Biflavonoids from Ginkgo Biloba L. Male Flowers In Vitro

Anticancer Effects of Five Biflavonoids from Ginkgo Biloba L. Male Flowers In Vitro

  • Molecules. 2019 Apr 16;24(8):1496. doi: 10.3390/molecules24081496.
Min Li 1,  Bin Li 2,  Zi-Ming Xia 3,  Ying Tian 4,  Dan Zhang 5 6,  Wen-Jing Rui 7,  Jun-Xing Dong 8,  Feng-Jun Xiao 9
Affiliations

Affiliations

  • 1 Beijing Institute of Radiation Medicine, Beijing 100850, China. limin82057@163.com.
  • 2 Beijing Institute of Radiation Medicine, Beijing 100850, China. jkylibin@hotmail.com.
  • 3 Beijing Institute of Radiation Medicine, Beijing 100850, China. naisixx@163.com.
  • 4 Beijing Institute of Radiation Medicine, Beijing 100850, China. hq6106@aliyun.com.
  • 5 Beijing Institute of Radiation Medicine, Beijing 100850, China. danzhang01@foxmail.com.
  • 6 School of Nursing, Jilin University, Changchun 130012, China. danzhang01@foxmail.com.
  • 7 Beijing Institute of Radiation Medicine, Beijing 100850, China. 18232627383@163.com.
  • 8 Beijing Institute of Radiation Medicine, Beijing 100850, China. djx931314@163.com.
  • 9 Beijing Institute of Radiation Medicine, Beijing 100850, China. 13911661105@163.com.
PMID: 30995808 DOI: 10.3390/molecules24081496
Abstract

Ginkgo biloba L., an ancient dioecious gymnosperm, is now cultivated worldwide for landscaping and medical purposes. A novel biflavonoid-amentoflavone 7''-O-β-D-glucopyranoside (1)-and four known biflavonoids were isolated and identified from the male flowers of Ginkgo. The anti-proliferative activities of five biflavonoids were evaluated on different Cancer lines. Bilobetin (3) and isoginkgetin (4) exhibited better anti-proliferative activities on different Cancer lines. Their effects were found to be cell-specific and in a dose and time dependent manner for the most sensitive HeLa cells. The significant morphological changes validated their Anticancer effects in a dose-dependent manner. They were capable of arresting the G2/M phase of the cell cycle, inducing the Apoptosis of HeLa cells dose-dependently and activating the proapoptotic protein Bax and the executor Caspase-3. Bilobetin (3) could also inhibit the antiapoptotic protein Bcl-2. These might be the mechanism underlying their anti-proliferation. In short, bilobetin (3) and isoginkgetin (4) might be the early lead compounds for new Anticancer agents.

Keywords

Ginkgo biloba flowers; anticancer; biflavonoids; bilobetin; isoginkgetin.

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