1. Academic Validation
  2. Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury

Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury

  • Front Biosci (Landmark Ed). 2020 Jan 1;25(3):480-497. doi: 10.2741/4815.
Li-Zhi Gu 1 Hong Sun 2
Affiliations

Affiliations

  • 1 Department of Emergency, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, glzhayy@sina.com.
  • 2 Department of Emergency, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
PMID: 31585898 DOI: 10.2741/4815
Abstract

Acute lung injury (ALI) is a life-threatening condition caused by severe inflammation of lung tissues. We hypothesized that lipopolysaccharide induced acute lung inflammation and injury in mice might be controlled by lonicerin (LCR), a plant flavonoid that impacts immunity, oxidative stress, and cell proliferation. LCR reduced pathological changes including pulmonary edema, elevation of protein in bronchoalveolar lavage, inflammation, pro-inflammatory gene expression, expression of Toll-like Receptor 4/nuclear factor-kappa B, Apoptosis, and significantly reduced mortality. Together, the results suggest that LCR might be a potential and effective candidate for the treatment of ALI that acts by inhibiting inflammation and Apoptosis.

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