1. Academic Validation
  2. Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity

Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity

  • J Nanobiotechnology. 2022 Nov 3;20(1):468. doi: 10.1186/s12951-022-01682-5.
Xiaowen Zhong 1 Chenyang Li 1 Guangzong Zhao 1 Mengmeng Li 1 Shuning Chen 1 Yang Cao 2 Qi Wang 3 Jiangchuan Sun 1 Shenyin Zhu 4 Shufang Chang 5
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
  • 2 Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
  • 3 State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
  • 4 Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, People's Republic of China. zhushenyin@cqmu.edu.cn.
  • 5 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China. 300502@cqmu.edu.cn.
Abstract

The hypoimmunogenicity of tumors is one of the main bottlenecks of Cancer Immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of tumor immunotherapy by increasing antigen exposure and presentation, and establishing an inflammatory microenvironment. Here, a multifunctional antigen trapping nanoparticle with indocyanine green (ICG), aluminum hydroxide (Al(OH)3) and oxaliplatin (OXA) (PPIAO) has been developed for tumor photoacoustic/ultrasound dual-modality imaging and therapy. The combination of photothermal/photodynamic therapy and chemotherapy induced tumor antigen exposure and release through immunogenic death of tumor cells. A timely capture and storage of antigens by aluminum hydroxide enabled dendritic cells to recognize and present those antigens spatiotemporally. In an ovarian tumor model, the photoacoustic-mediated PPIAO NPs combination therapy achieved a transition from "cold tumor" to "hot tumor" that promoted more CD8+ T lymphocytes activation in vivo and intratumoral infiltration, and successfully inhibited the growth of primary and metastatic tumors. An in situ tumor vaccine effect was produced from the treated tumor tissue, assisting mice against the recurrence of tumor cells. This study provided a simple and effective personalized tumor vaccine strategy for better treatment of metastatic and recurrent tumors. The developed multifunctional tumor antigen trapping nanoparticles may be a promising nanoplatform for integrating multimodal imaging monitoring, tumor treatment, and tumor vaccine immunotherapy.

Keywords

Antigen capture; Immunogenic cell death; Photoacoustic imaging; Photodynamic therapy; Photothermal therapy; Tumor immunotherapy.

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