2. Academic Validation
  3. Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells

Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells

  • J Nanobiotechnology. 2023 Mar 21;21(1):99. doi: 10.1186/s12951-023-01856-9.
Hao Yu # 1,  Yun Teng # 1,  Jun Ge 1,  Ming Yang 1,  Haifeng Xie 1,  Tianyi Wu 1,  Qi Yan 1,  Mengting Jia 2,  Qing Zhu 2,  Yanping Shen 3,  Lianxue Zhang 4,  Jun Zou 5
Affiliations

Affiliations

  • 1 Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 188 Shizi St., Suzhou, 215006, Jiangsu, China.
  • 2 Department of Nephrology, The First Affiliated Hospital of Soochow University, 188 Shizi St., Suzhou, 215006, Jiangsu, China.
  • 3 Department of Nephrology, The First Affiliated Hospital of Soochow University, 188 Shizi St., Suzhou, 215006, Jiangsu, China. shenyanping@suda.edu.cn.
  • 4 College of Life Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou, 310027, Zhejiang, China. lianxuezhang@zju.edu.cn.
  • 5 Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 188 Shizi St., Suzhou, 215006, Jiangsu, China. jzou@suda.edu.cn.
  • # Contributed equally.
PMID: 36941611 DOI: 10.1186/s12951-023-01856-9
Abstract

Excessive Reactive Oxygen Species (ROS) in nucleus pulposus cells (NPCs) promote extracellular matrix (ECM) degradation and cellular inflammatory responses by activating a variety of cellular pathways, ultimately inducing cell Apoptosis and leading to the development of low back pain. Here, we designed and fabricated an isoginkgetin-loaded ROS-responsive delivery system (IGK@SeNP) based on diselenide block copolymers. Successfully encapsulated IGK was released intelligently and rapidly in a microenvironment with high ROS levels in degenerative disc. Controlled-release IGK not only efficiently scavenged ROS from the intervertebral disc together with diselenide block copolymers but also effectively enhanced Autophagy in NPCs to inhibit ECM degradation and cell Apoptosis, and showed significant therapeutic effects in the rat intervertebral disc degeneration (IDD) model. Overall, the synergistic effects of IGK@SeNP in ROS scavenging and Autophagy enhancement endowed it with an attractive therapeutic strategy for IDD treatment.

Keywords

Autophagy; Diselenide-containing nanoparticles; Intervertebral disc degeneration; Isoginkgetin; Reactive oxygen species (ROS)-responsive drug release.

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