2. Academic Validation
  3. Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress

Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress

  • J Asian Nat Prod Res. 2023 Oct 27:1-13. doi: 10.1080/10286020.2023.2269370.
Yin-Yuan Wang 1 2,  Jian-Cheng Ni 3,  Yue-Qin Zhao 1 4,  Xu Yang 1 4,  Zhen-Peng Niu 1 5 6,  Xing-Zhi Yang 1,  Xian-Xiang Dong 1 4,  Yu-Han Zhao 1,  Xiao-Jiang Hao 1 5,  Xiao Ding 1 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • 2 School of Life Sciences, Yunnan University, Kunming 650091, China.
  • 3 The Engineering Technology Research Center of Characteristic Medicinal Plants of Fujian, Ningde Normal University, Ningde 352100, China.
  • 4 University of Chinese Academy of Sciences, Beijing 100049, China.
  • 5 Research Unit of Chemical Biology of Natural Anti-Virus Products, Chinese Academy of Medical Sciences, Beijing 100730, China.
  • 6 School of Basic Medicine, Guizhou Medical University, Guiyang 550009, China.
PMID: 37897053 DOI: 10.1080/10286020.2023.2269370
Abstract

Morinda officinalis is a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated from M. officinalis were evaluated for their roles in the autophagy-lysosomal pathway. All three iridoid glycosides could induce TFEB/TFE3-mediated lysosomal biogenesis and trigger Autophagy. Interestingly, they promoted the nuclear import of TFEB/TFE3 without affecting their nuclear export, suggesting their role in the maintenance of lysosomal homeostasis. The results from this study shed LIGHT on the identification of Autophagy activators from M. officinalis and provide a basis for developing them in the treatment of oxidative stress-involved diseases.

Keywords

Iridoid glycosides; Morinda officinalis; TFEB/TFE3; antioxidant activity; lysosomal biogenesis.

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