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  2. Developing a novel magnetic organic polymer for selective extraction and determination of 16 macrolides in water and honey samples

Developing a novel magnetic organic polymer for selective extraction and determination of 16 macrolides in water and honey samples

  • RSC Adv. 2024 Mar 18;14(13):8726-8734. doi: 10.1039/d4ra00496e.
Mengnan Liang 1 Na Li 1 Hao Zhang 1 Ling Ma 2 3 Ke Wang 1 2 3
Affiliations

Affiliations

  • 1 College of Chemistry and Materials Science, Hebei Normal University Shijiazhuang 050023 China wkecdc@163.com.
  • 2 Shijiazhuang Center for Disease Control and Prevention Shijiazhuang 050011 China mamalin001@163.com.
  • 3 Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning Shijiazhuang 050011 China.
Abstract

A novel magnetic organic polymer Fe3O4@SiO2@Tb-PDAN was designed and synthesized, which was used as an adsorbent for magnetic solid-phase extraction (MSPE) of 16 macrolides (MALs) in water and honey. The synthesized adsorbent was characterized using techniques including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). Then several parameters of the extraction process were further optimized. Under the optimized conditions, an MSPE-LC-MS/MS method was established for extraction and determination of 16 MALs, which showed good linearity (r ≥ 0.999), low limits of detection (0.001-0.012 μg L-1 for water and 0.001-0.367 μg kg-1 for honey) and satisfactory recoveries (70.02-118.91%) with the relative standard deviations (RSDs) lower than 10.0%. This established method was then successfully applied to detect MALs in real samples, which suggested that Fe3O4@SiO2@Tb-PDAN was a potential magnetic adsorbent for efficient extraction and analysis of MALs.

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