2. PROTAC Immunology/Inflammation
  3. PROTACs Macrophage migration inhibitory factor (MIF)
  4. MD13

MD13 是一种巨噬细胞迁移抑制因子 (MIF) 导向的 PROTAC，Ki 值为 71 nM。MD13 可用于癌症研究。

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MD13 Chemical Structure

MD13 Chemical Structure

CAS No. : 2758431-97-7

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规格 价格 是否有货 数量
5 mg ￥8640
3 - 4 周
10 mg   询价  
50 mg   询价  

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MD13 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research[1].

IC50 & Target

Ki: 71 nM (MIF)[1]
体外研究
(In Vitro)

MD13 degrades 91±5% and 71±7% MIF at 2 μM and 0.2 μM, respectively. MD13 induces MIF degradation through binding to E3 ligase cereblon[1].
MD13 (0-20 μM; 72 h) inhibits cell proliferation of A549 cancer cells[1].
MD13 (1-5 μM; 48 h) arrests cell cycle at G2/M phase in A549 cells[1].
MD13 (2 μM; 6-48 h) inhibits ERK signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MD13 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0-20 μM
Incubation Time: 12 h
Result: Caused depletion of MIF protein.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 2 μM
Incubation Time: 6, 24 or 48 h
Result: Inhibited ERK phosphorylation.

Cell Proliferation Assay[1]

Cell Line: A549 cells
Concentration: 0-20 μM
Incubation Time: 72 h
Result: Inhibited the growth of A549 cells in a dose-dependent manner. The inhibitory effect reached about 50% inhibition of cell proliferation at a concentration of 20 µM.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 1, 2, or 5 μM
Incubation Time: 48 h
Result: Dose-dependently induced cell cycle arrest at the G2/M phase.
分子量

653.68

Formula

C35H35N5O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MD13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD132758431-97-7MD 13MD-13PROTACsMacrophage migration inhibitory factor (MIF)A549MIFmacrophage migration inhibitory factoranticancerERK signalingInhibitorinhibitorinhibit

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产品名称：
MD13
目录号：
HY-148117
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