2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein Immunology/Inflammation
  3. nAChR Histamine Receptor
  4. Mecamylamine

Mecamylamine  (Synonyms: 美加明)

目录号: HY-B1395A
产品使用指南

摩尔计算器

Mecamylamine 是一种具有口服活性，非选择性，非竞争性的 nAChR 拮抗剂。Mecamylamine 也是一种神经节阻滞剂，可穿过血脑屏障。Mecamylamine 可用于神经疾病，高血压，抗抑郁的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Mecamylamine hydrochloride 通常具有更好的水溶性和稳定性。

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Mecamylamine Chemical Structure

Mecamylamine Chemical Structure

CAS No. : 60-40-2

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Mecamylamine 的其他形式现货产品:

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Other Forms of Mecamylamine:

Mecamylamine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[1][2][5].

IC50 & Target

nAChR[1], histamine receptor[2]
体外研究
(In Vitro)

Mecamylamine (0.5-9 μM, bath administered) increases the firing frequency of identified 5-HT DRN (dorsal raphe nucleus) neurons[1].
Mecamylamine (0.5-9 μM, bath administered) increases the glutamatergic and decreases the GABAergic input of 5-HT DRN neurons[1].
Mecamylamine (1 mM, 5 min) blocks the histamine receptor and the histamine-induced contractions in helically cut strips of rabbit aorta[2].
Mecamylamine (10 μM,48 h) attenuates the effect of nicotine’s action of neuroprotection[3].
Mecamylamine (1-100 nM, 30 min) dose-dependently attenuates endothelial tube formation in HDMVECs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mecamylamine 相关抗体:

Western Blot Analysis[3]

Cell Line: SCG neurons
Concentration: 10 μM
Incubation Time: 48 h
Result: Reduced the nicotine-facilitated increase in ERK1/2.
体内研究
(In Vivo)

Mecamylamine (subcutaneous pumps, 50 mg/kg/day, 2 days) inhibits choroidal neovascularization (CNV) in CNV mice model[4].
Mecamylamine (intraperitoneal injection, 0.5-1 mg/kg) has antidepressant-like effects in both the TST (tail suspension test) and FST (forced swim test) in C57BL/6J mice, which are dependent on both β2 and α7 subunits[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Choroidal neovascularization (CNV) mice model[1]
Dosage: 50 mg/kg/day, 2 days
Administration: Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h.
Result: Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine.
Animal Model: C57BL/6J mice[5]
Dosage: 0.5-1 mg/kg
Administration: Intraperitoneal injection
Result: Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.
Clinical Trial
分子量

167.29

Formula

C11H21N
CAS 号
中文名称

美加明
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mecamylamine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mecamylamine60-40-2美加明nAChRHistamine ReceptorNicotinic acetylcholine receptorsNeuropsychiatricganglionichypertensionblood-brain barriervoltage-dependentneuronantidepressantvascularizationCNVFSTTSTtail suspensionforced swimInhibitorinhibitorinhibit

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