1. Cell Cycle/DNA Damage
  2. Antifolate DNA/RNA Synthesis
  3. Methotrexate α-tert-butyl ester

Methotrexate α-tert-butyl ester 

目录号: HY-133887 纯度: ≥96.0%
COA 产品使用指南

Methotrexate α-tert-butyl ester,经 OtBu 修饰,显著降低 HT1080 荷瘤小鼠的肿瘤生长。Methotrexate 是一种抗代谢和抗叶叶酸剂,也是一种免疫抑制剂和抗肿瘤活性分子。

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Methotrexate α-tert-butyl ester Chemical Structure

Methotrexate α-tert-butyl ester Chemical Structure

CAS No. : 79640-70-3

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent[1][2][3][4].

体外研究
(In Vitro)

OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice[1].
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells)[1]
Dosage: 30 mg/kg
Administration: Once per week for 2 weeks
Result: Showed a significant (63%) reduction in tumor size on day 12.
分子量

510.55

Formula

C24H30N8O5

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Methotrexate α-tert-butyl ester 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Methotrexate α-tert-butyl ester
目录号:
HY-133887
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