2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Mirvetuximab soravtansine

Mirvetuximab soravtansine  (Synonyms: IMGN853)

目录号: HY-132258
COA 产品使用指南

摩尔计算器

Mirvetuximab soravtansine (IMGN853) 是一种抗体药物偶联物 (ADC)，由细胞毒性 maytansoid DM4 组成，共价连接到人源化单克隆抗体 M9346A。Mirvetuximab soravtansine 选择性结合叶酸受体1 (FOLR1)。Mirvetuximab soravtansine 具有抑制生长和增强 DNA 损伤的抗增殖作用。

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Mirvetuximab soravtansine Chemical Structure

Mirvetuximab soravtansine Chemical Structure

CAS No. : 1453084-37-1

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Mirvetuximab soravtansine 的其他形式现货产品:

Customer Review

Other Forms of Mirvetuximab soravtansine:

Mirvetuximab soravtansine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mirvetuximab soravtansine (IMGN853) is an antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage[1].

体外研究
(In Vitro)

Mirvetuximab soravtansine (IMGN853; 8 nM; 6 h; IGROV-1 细胞) 与 Carboplatin (HY-17393) 的结合在体外促进协同生长抑制作用和细胞周期扰动[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mirvetuximab soravtansine 相关抗体:

Cell Cycle Analysis[1]

Cell Line: IGROV-1 cells
Concentration: 8 nM; 20 μM (Carboplatin)
Incubation Time: 6 h
Result: Had almost half of all viable cells accumulating in G2/M.

Western Blot Analysis[1]

Cell Line: IGROV-1 cells
Concentration: 8 nM; 20 μM (Carboplatin)
Incubation Time: 6 h
Result: Induced γH2AX expression in IGROV-1 cells and to levels higher than those seen following carboplatin exposure alone.
体内研究
(In Vivo)

Mirvetuximab soravtansine (IMGN853; 5 mg/kg; i.v.; SCID 雌性小鼠患者来源的异种移植模型) 增强 Carboplatin 的体内抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female severe combined immunodeficient (SCID) mice with patient-derived xenografts[1]
Dosage: 5 mg/kg; 80 mg/kg (Carboplatin)
Administration: Intravenous injection; two consecutive weekly doses
Result: Suppressed tumor growth and combination therapy induced the greatest degree of tumor growth inhibition.
Clinical Trial
分子量

150000.00

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: 99.90%

COA (173 KB) Others (215 KB)

产品使用指南 (1538 KB)
参考文献

Mirvetuximab soravtansine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mirvetuximab soravtansine1453084-37-1IMGN853IMGN 853IMGN-853Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesmaytansoid DM4M9346AFOLR1DNA damageIGROV-1 cellsInhibitorinhibitorinhibit

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目录号：
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