2. JAK/STAT Signaling Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. EGFR CDK VEGFR
  4. Multi-target kinase inhibitor 2

Multi-target kinase inhibitor 2 

目录号: HY-149636
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摩尔计算器

Multi-target kinase inhibitor 2 (compound 5K) 是一种 multi-targeted kinase 抑制剂，具有抑制 EGFR、Her2、VEGFR2 和 CDK2 酶的活性，其 IC50 值范围为 40 ~ 204 nM。Multi-target kinase inhibitor 2 对 HepG2、HeLa、MDA-MB-231 和 MCF-7 均有细胞毒作用，IC50 值分别为 41、57、51 和 59 μM。Multi-target kinase inhibitor 2 诱导 HepG2 细胞周期阻滞和凋亡 (apoptosis)。

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Multi-target kinase inhibitor 2 Chemical Structure

Multi-target kinase inhibitor 2 Chemical Structure

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Multi-target kinase inhibitor 2 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-target kinase inhibitor 2 (compound 5K) is a multi-targeted kinase inhibitor, and exhibits activity against EGFR, Her2, VEGFR2, and CDK2 enzymes, with IC50 values ranging from 40 to 204 nM. Multi-target kinase inhibitor 2 shows cytotoxic effects were observed against HepG2, HeLa , MDA-MB-231 and MCF-7, with IC50 of 41, 57, 51 and 59 μM. Multi-target kinase inhibitor 2 induces cell cycle arrest and apoptosis in HepG2 cells.

分子量

425.27

Formula

C20H14Cl2N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-target kinase inhibitor 2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-target kinase inhibitor 2EGFRCDKVEGFREpidermal growth factor receptorErbB-1HER1Cyclin dependent kinaseVascular endothelial growth factor receptorPyrrolo[2,3-d]pyrimidineapoptosis inducertyrosine kinase inhibitormultiple kinase inhibitorInhibitorinhibitorinhibit

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