2. Cell Cycle/DNA Damage Anti-infection Apoptosis
  3. DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
  4. Neocarzinostatin

Neocarzinostatin  (Synonyms: Zinostatin; Vinostatin)

目录号: HY-111183 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Neocarzinostatin 是一种有效的 DNA 损伤的、抗肿瘤抗生素，可识别双链 DNA 膨胀并诱导DNA双链断裂 (DSBs)。Neocarzinostatin 诱导细胞凋亡 (apoptosis)。Neocarzinostatin 具有用于 EpCAM 阳性肿瘤的潜力。

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Neocarzinostatin Chemical Structure

Neocarzinostatin Chemical Structure

CAS No. : 9014-02-2

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规格 价格 是否有货 数量
100 μg (0.62 mg/mL * 1mL in 20 mM MES buffer pH=5.5) ￥17000
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Neocarzinostatin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2].

体外研究
(In Vitro)

The EpCAM aptamer conjugated Neocarzinostatin (NCS) shows specificity to EpCAM-positive cells. The effects of the conjugates on cancer cells are impressive as the conjugate arrests the cell cycle and promoted apoptosis and necrosis. The high levels of PARP expression confirmed the DNA breaks upon conjugate treatment. NCS conjugated with EpCAM can be targeted to cancer cells sparing normal cells[3].
The IC50 values of Neocarzinostatin (72 hours) to C6 cells and U87MG cells were 493.64 nM, 462.96 nM, respectively[4].
In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neocarzinostatin 相关抗体:
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (184 KB)

产品使用指南 (1538 KB)
参考文献

Neocarzinostatin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neocarzinostatin9014-02-2Zinostatin VinostatinDNA/RNA SynthesisBacterialApoptosisAntibioticDNA-damaginganti-tumordoublestrandbreaksEpCAM-positivecancerBcl-2necrosisU87MGcellsInhibitorinhibitorinhibit

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