2. NF-κB
  3. NF-κB
  4. NF-κB-IN-12

NF-κB-IN-12 (compound 3h) 是一种有效的 NF-κB 抑制剂，IC50 为 1.02 μM。NF-κB-IN-12 可用于急性肺损伤研究。

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NF-κB-IN-12 Chemical Structure

NF-κB-IN-12 Chemical Structure

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NF-κB-IN-12 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor, with an IC50 of 1.02 μM. NF-κB-IN-12 can be used for acute lung injury research[1].

IC50 & Target

IC50: 1.02 ± 0.29 μM (NF-κB)[1]
体外研究
(In Vitro)

NF-κB-IN-12 (compound 3h) 对 MCF-12A 细胞(正常上皮细胞)无毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-12 相关抗体:
体内研究
(In Vivo)

NF-κB-IN-12 (compound 3h) (5-10 mg/kg，IP，每日)对 SD 大鼠显示出对 CLP (盲肠结扎穿刺)方法诱导的脓毒症的保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (male, 7-9 weeks old, weighing 210-260 g)[1]
Dosage: 5, 10 mg/kg
Administration: IP, daily for 3 days before CLP surgery and on the 4th day 1 h before CLP
Result: Significantly upregulated SOD and GSH. Improved the antioxidant status of experimental rats. Reduced the elevated level of nuclear NF-ĸB. Caused a significant reduction in lung edema and total proteins, mononuclear leukocytes, and polymorphonuclear leukocytes in BALF (bronchoalveolar lavage fluid).
分子量

582.63

Formula

C30H26N6O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NF-κB-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-12NF-κBNuclear factor-κBNuclear factor-kappaBMCF-12Aanti-inflammatorysepsisacute lung injuryInhibitorinhibitorinhibit

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