2. MAPK/ERK Pathway
  3. MAP3K MAP4K
  4. NG25 trihydrochloride

NG25 trihydrochloride 是一种 TAK1 和 MAP4K2 双重抑制剂 (IC50 分别为 149 nM 和 21.7 nM)。NG25 trihydrochloride 使乳腺癌细胞对 Doxorubicin (HY-15142A) 敏感，并增强细胞凋亡 (apoptosis)。NG25可用于多种癌症的研究。

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NG25 trihydrochloride Chemical Structure

NG25 trihydrochloride Chemical Structure

CAS No. : 2108554-00-1

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NG25 trihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 24 篇科研文献

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    NG25 trihydrochloride purchased from MCE. Usage Cited in: Sci Signal. 2018 Jul 10;11(538). pii: eaan5850.  [Abstract]

    A549 cells are treated for 30 min with either 5z-7-oxozeanol or NG-25 to inhibit TAK1 and immunoblotted with the indicated antibodies.

    NG25 trihydrochloride purchased from MCE. Usage Cited in: Mol Med Rep. 2018 Jan;17(1):1710-1716.  [Abstract]

    Expression level of p TAK1 and downstream targets following NG25 treatment. Western blot detection of p TAK1 and TAK1 expression levels in the sham group, and samples from HI, DMSO treated and NG25 treated rat brain cortexes.

    NG25 trihydrochloride purchased from MCE. Usage Cited in: Nat Cell Biol. 2017 Oct;19(10):1248-1259.  [Abstract]

    Immortalized RIPK1 +/+ fetal liver mouse macrophages were infected with YopP-negative Ye-ΔyopP in presence of inhibitors for TAK1 (NP, NG25), IKKβ, IKK, p38, MK2, JNK, or MEK1/ERK. The phosphorylation of RIPK1 is analyzed by immunoblotting in cell lysates prepared after 75 min of infection.

    NG25 trihydrochloride purchased from MCE. Usage Cited in: Oncogene. 2017 Oct 5;36(40):5620-5630.  [Abstract]

    C3-TAg cells are starved and stimulated for 0, 15 and 30 min with ephrin-A1-Fc (EphA2 ligand; 1 μg/mL) in the presence or absence of ALW-II-41-27 or NG-25 control. EphA2 is immunoprecipitated and products probed for tyrosine phosphorylation and EphA2. ALW-II-41-27 significantly reduces basal and ephrin-A1-Fc induced tyrosine phosphorylation.

    NG25 trihydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2017 Nov 1;8(61):104330-104346.  [Abstract]

    MC38-CT or -CC1-L cells are treated with 1 μM of DMSO, or the non-specific NG-25 or specific ALW-II-41-27 EPHA2 receptor inhibitor for indicated periods of time, followed by stimulation with EFNA1-Fc (2 μg/mL) in the last 15 min of treatments. Protein lysates are prepared and subjected to immunoblotting using antibodies to determine the effect of kinase inhibitors on EPHA2 activation.

    NG25 trihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2016 Sep 7;6:32737.  [Abstract]

    TAK1 inhibition inhibits Dox-induced p38 activation and IκBα degradation. Breast cancer cell lines T-47D, MCF7, HCC1954, MDA-MB-231, and BT-549 are treated with Dox (20 μM) alone or combined with NG25 (2 μM) for 0, 2 h, 4 h or 6 h. The protein extracts are subjected to SDS-PAGE and immunoblotted with the antibodies against p-p38, p38, and IκBα. β-actin are detected as loading controls for whole cell extracts.

    NG25 trihydrochloride purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2014 Oct 10;453(1):106-11.  [Abstract]

    786-O/A489 RCC cells are treated with LYTAK1 (100 nM), 5Z-7-oxozeanol (5Z, 0.25 lM) or NG-25 (NG-25, 2.5 lM) for 24 h, Western blots are applied to tested list proteins.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    NG25 trihydrochloride is a dual TAK1 and MAP4K2 inhibitor (IC50: 149 nM and 21.7 nM respectively). NG25 sensitizes the breast cancer cells to Doxorubicin (HY-15142A), and enhances apoptosis. NG25 trihydrochloride can be used for research of various cancers[1][2].

    分子量

    646.96

    Formula

    C29H33Cl3F3N5O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    NG25 trihydrochloride 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NG25 trihydrochloride2108554-00-1MAP3KMAP4KMAP kinase kinase kinase, MEKK, MAPKKKMAPK Kinase Kinase KinaseDoxorubicinbreast cancercolorectal cancerInhibitorinhibitorinhibit

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