2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. NGB 2904 hydrochloride

NGB 2904 hydrochloride 是一种有效，选择性，具有口服活性和可透过血脑屏障的多巴胺 D3 受体的拮抗剂，Ki 值为 1.4 nM。NGB 2904 hydrochloride 对 D3 的选择性高于 D2，5-HT2，α1，D4，D1 和 D5 受体 (Ki=217，223，642，>5000，>10000 和 >10000 nM)。NGB 2904 hydrochloride 可拮抗 Quinpirole 刺激的有丝分裂。

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NGB 2904 hydrochloride Chemical Structure

NGB 2904 hydrochloride Chemical Structure

CAS No. : 189061-11-8

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NGB 2904 hydrochloride 的其他形式现货产品:

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NGB 2904 hydrochloride 相关抗体

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis[1][2].

IC50 & Target[1]

D3 Receptor

1.4 (Ki)

体外研究
(In Vitro)

NGB 2904 拮抗 Quinpirole (100 nM) 刺激的有丝分裂发生，IC50 为 5.0 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NGB 2904 hydrochloride 相关抗体:
体内研究
(In Vivo)

NGB 2904 (26 μg/kg；单次皮下注射) 增强苯丙胺 (26 mg/kg) 刺激的野生型小鼠运动[3]。
NGB 2904 (0.026 μg-1 mg/kg；单次皮下注射或每天一次，持续 7 天) 刺激野生型小鼠的自发运动[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

530.92

Formula

C28H30Cl3N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NGB 2904 hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NGB 2904189061-11-8NGB2904NGB-2904Dopamine ReceptordopamineD3QuinpirolemitogenesisreinstatementInhibitorinhibitorinhibit

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