2. Anti-infection
  3. HIV Reverse Transcriptase
  4. Nigranoic acid

Nigranoic acid 

目录号: HY-122935 纯度: ≥95.0%
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Nigranoic acid 是五味子中分离得到的一种三萜类化合物。Nigranoic acid 能抑制 HIV-1 逆转录酶。在脑缺血再灌注动物模型中，Nigranoic acid 通过 PARP/AIF 信号通路保护大脑。

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Nigranoic acid Chemical Structure

Nigranoic acid Chemical Structure

CAS No. : 39111-07-4

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Nigranoic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2].

IC50 & Target

HIV-1 reverse transcriptase
体内研究
(In Vivo)

Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2].
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2]
Dosage: 1 mg/kg
Administration: Intragastric; 6 hours and 2 hours before brain ischemia
Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
分子量

470.68

Formula

C30H46O4
CAS 号
性状

固体

颜色

Off-white to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (260 KB)

产品使用指南 (1538 KB)
参考文献

Nigranoic acid 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Nigranoic acid39111-07-4HIVReverse TranscriptaseHuman immunodeficiency virusHIV-1reversetranscriptaseischemia-reperfusionInhibitorinhibitorinhibit

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