2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Nitracrine dihydrochloride hydrate

Nitracrine dihydrochloride hydrate 

目录号: HY-U00279A
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摩尔计算器

Nitracrine (dihydrochloride hydrate) 抑制 RNA 合成 (RNA synthesis)，共价，可逆地与 DNA 结合，在体内与 DNA 形成共价加合物。Nitracrine (dihydrochloride hydrate) 是 1-nitroacridine 衍生物，一种有效的体外缺氧选择性活性分子和抗肿瘤活性分子。Nitracrine (dihydrochloride hydrate) 具有细胞毒性。

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Nitracrine dihydrochloride hydrate Chemical Structure

Nitracrine dihydrochloride hydrate Chemical Structure

CAS No. : 55429-45-3

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Nitracrine dihydrochloride hydrate 的其他形式现货产品:

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Other Forms of Nitracrine dihydrochloride hydrate:

Nitracrine dihydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nitracrine (dihydrochloride hydrate) inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine (dihydrochloride hydrate), a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine (dihydrochloride hydrate) has cytotoxicity towards most cells[1][2][3].

体外研究
(In Vitro)

Nitracrine (2 μM; 1 h) 在光照 48 min 下导致 50% 的人红白血病 K562 细胞死亡。而在黑暗中的作用时间为 8.5 h[3]。
硝克林在 P388 细胞、NIH3T3 细胞和 K562 细胞中的 LD50 值分别为 0.23 μM、0.6 μM 和 0.16 μM, 细胞光照下孵育 1 小时后，[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nitracrine dihydrochloride hydrate 相关抗体:

Cell Viability Assay[3]

Cell Line: Human erythroleukemia K562 cells
Concentration: 2 μM
Incubation Time: 1h
Result: Death of 50% of human erythroleukemia K562 cells were achieved under illumination for 48 min.
分子量

415.31

Formula

C18H24Cl2N4O3
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nitracrine dihydrochloride hydrate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitracrine dihydrochloride55429-45-3DNA/RNA Synthesis1-nitroacridinederivativehypoxia-selectiveantitumorDNAcovalentadductscytotoxicityInhibitorinhibitorinhibit

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