2. MAPK/ERK Pathway
  3. p38 MAPK
  4. NJK14047

NJK14047 抑制 p38 MAPK 以及 T 细胞向 Th1 和 Th17 细胞的分化。NJK14047 可改善胶原诱导的类风湿性关节炎和 Imiquimod (HY-B0180) 诱导的银屑病。

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NJK14047 Chemical Structure

NJK14047 Chemical Structure

CAS No. : 1800576-41-3

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NJK14047 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NJK14047 inhibits p38 MAPK and the differentation of naive T-cells to Th1 and Th17 cells. NJK14047 ameliorates the collage-induced rheumatoid arthritis and Imiquimod (HY-B0180)-induced psoriasis in mice[1].

体外研究
(In Vitro)

NJK14047 (3-10 μM) 抑制 Lipopolysaccharid (HY-D1056) 刺激的人 SW982 滑膜细胞中炎症细胞因子 IL-1β，TNF-α，IL-6，IL-17A，RANKL 和 MMP-3 的表达[ 1]。
NJK14047 (3-10 μM) 剂量依赖性地抑制初始 CD4+T 细胞向 Th1、Th2 和 Th17 细胞分化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NJK14047 相关抗体:
体内研究
(In Vivo)

NJK14047 (2.5 mg/kg，腹腔注射，7-21 天) 可改善 DBA-1J 小鼠模型中胶原诱导的类风湿性关节炎 (CIA) 和 BALB/c 小鼠模型中 Imiquimod (HY-B0180) 诱导的银屑病 (IIP)，抑制 Th1，Th2，Th17 和 Treg细胞因子表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: collage-induced rehumatoid arthritis in DBA-1J mice and imiquimod-induced psoriasis in BALB/c mice[1]
Dosage: 2.5 mg/kg
Administration: i.p. for 7 days for IIP-administrated BALB/c mice, i.p. for 21 days for CIA-administrated CBA-1J mice
Result: Ameliorated the collage-induced arthritis and CIA caused cartilage damage, inflammation, pannus formation, bone corrosion, and synovial hyperplasia.
Ameliorated the imiquimod induced psoriasis and IIP caused keratinocyte proliferation.
分子量

445.51

Formula

C27H27NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NJK14047 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NJK140471800576-41-3NJK 14047NJK-14047p38 MAPKDBA-1J mouseBALB/cSW982arthritispsoriasisInhibitorinhibitorinhibit

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HY-120225
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