2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Bacterial Antibiotic
  4. Nogalamycin

Nogalamycin 是一种羟硝氨糖环素。Nogalamycin 是抗革兰氏阳性细菌的有效抗生素，对某些肿瘤细胞也具有细胞毒性。Nogalamycin 由 Streptomyces nogalater var. Nogalater 菌株产生。Nogalamycin 与 DNA 模板结合后选择性抑制 RNA 合成。可用于抗癌研究。

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Nogalamycin Chemical Structure

Nogalamycin Chemical Structure

CAS No. : 1404-15-5

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1 mg ￥2000
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Nogalamycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer[1][2].

IC50 & Target

RNA Synthesis[2]
体外研究
(In Vitro)

Nogalamycin (0-10 μg/ml; 2 hours) exhibits lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nogalamycin 相关抗体:

Cell Cytotoxicity Assay

Cell Line: CHO, L1210 and B16 cells[1]
Concentration: 0-10 μg/ml
Incubation Time: 2 hours
Result: Exhibited lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml.
体内研究
(In Vivo)

Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 0-1000 mug/kg
Administration: IP
Result: Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg.
分子量

787.80

Formula

C39H49NO16
CAS 号
性状

固体

颜色

Orange to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (12.69 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2694 mL 6.3468 mL 12.6936 mL
5 mM 0.2539 mL 1.2694 mL 2.5387 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥97.0%

COA (273 KB)

产品使用指南 (1538 KB)
参考文献

Nogalamycin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2694 mL 6.3468 mL 12.6936 mL 31.7339 mL
5 mM 0.2539 mL 1.2694 mL 2.5387 mL 6.3468 mL
10 mM 0.1269 mL 0.6347 mL 1.2694 mL 3.1734 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nogalamycin1404-15-5DNA/RNA SynthesisBacterialAntibioticAnticancerAntitumorCHOL1210B16CytotoxicityGram-positive bacteriaInhibitorinhibitorinhibit

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产品名称：
Nogalamycin
目录号：
HY-105846
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