NSC 689534 

NSC 689534 can form copper chelate with Cu²⁺. NSC 689534/Cu²⁺ complex is a potent oxidative stress inducer, and has antitumor activity^[1].

NSC 689534/Cu²⁺ 复合物 (48 h) 抑制 HL60 和 PC3 细胞的细胞活力，IC₅₀s 分别为 0.2 和 0.4 μM， 比单独使用 NSC 689534 更有效，约为 4 倍^[1]。
NSC 689534/Cu²⁺ 复合物 (2.5 μM，24 小时) 可诱导 PC3 细胞中的氧化应激并消耗 GSH，而单独使用 NSC 689534 则没有效果^[1]。
NSC 689534/Cu²⁺ 复合物 (2.5 μM，24 小时) 可诱导 PC3 细胞中的巨自噬 (通过 LC3 积累到大自噬体中) 和 ER 应激反应 (GRP78 和 CHOP 上调)^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 689534/Cu²⁺ 复合物 (3 mg/kg，腹腔注射，每天一次或两次，持续 5 天) 可抑制 HL60 异种移植模型中的肿瘤生长，而单独使用 NSC 689534 则没有统计学意义^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

362.45

C₁₉H₁₈N₆S

907958-80-9

固体

Light yellow to yellow

Room temperature in continental US; may vary elsewhere.

• [1]. Chad N Hancock, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.  [Content Brief]

  [2]. Hancock CN, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.  [Content Brief]