OD36 hydrochloride 

OD36hydrochloride is a RIPK2 inhibitor with an IC₅₀ of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with K_Ds of 37 nM^[1][2].

OD36 also inhibits ALK2 and ALK2 R206H with IC₅₀s of 47 and 22 nM, respevtively^[1].
OD36 shows activity against ALK1 with a K_D of 90 nM^[2].
OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation^[2].
OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells^[2].
Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

367.23

C₁₆H₁₆Cl₂N₄O₂

2387510-88-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Justine T Tigno-Aranjuez, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.  [Content Brief]

  [2]. Gonzalo Sánchez-Duffhues, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230.  [Content Brief]

  [3]. Tigno-Aranjuez JT, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.  [Content Brief]