1. Immunology/Inflammation
  2. Complement System
  3. Olendalizumab

Olendalizumab  (Synonyms: ALXN1007)

目录号: HY-P99767

Olendalizumab (ALXN1007) 是一种源自小鼠的人源化 IgG2-G4-κ 抗体,靶向补体蛋白 C5a (Ki=60 pM)。Olendalizumab 靶向补体炎症通路。并且,Olendalizumab 可用于研究由冠状病毒引起的补体介导的疾病。

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Olendalizumab Chemical Structure

Olendalizumab Chemical Structure

CAS No. : 2210314-30-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (Ki=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus[1][2].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Humanized

IC50 & Target

Complement protein C5a[1]

体外研究
(In Vitro)

Olendalizumab 可用作生物素化捕获试剂,在 Bioaffy wash 1 中的工作浓度为 100 μg/mL,同时 AlexaFluor 标记的抗 C5a 克隆 2942 在 Rexxip F 中的工作浓度为 4 μg/mL[1]
补体系统的成员,如 C3、C5a、C5b-9,包括受体,如 C3aR 和 C5aR,介导病毒感染后的肺损伤。 此外,C5/C5a 更是冠状病毒引起的肺损伤中的非沉默补体。Olendalizumab 是有效的 C5a 抑制剂[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
非同位 CAS

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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