2. Anti-infection
  3. Bacterial Antibiotic
  4. Omadacycline

Omadacycline  (Synonyms: PTK 0796; Amadacycline)

目录号: HY-14865 纯度: 98.75%
COA 产品使用指南

摩尔计算器

Omadacycline (PTK 0796) tosylate，首创的具有口服活性的氨基甲基环素抗菌剂，是一种四环素类抗生素。Omadacycline tosylate 通过与 30S 核糖体亚基结合来抑制细菌蛋白质的合成。Omadacycline tosylate 对多种细菌表现出活性，包括好氧和厌氧革兰氏阳性细菌和革兰氏阴性细菌，非典型病原体。Omadacycline tosylate 可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。

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Omadacycline Chemical Structure

Omadacycline Chemical Structure

CAS No. : 389139-89-3

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规格 价格 是否有货 数量
5 mg ￥1500
In-stock
10 mg ￥2400
In-stock
25 mg ￥4600
In-stock
50 mg   询价  
100 mg   询价  

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Other Forms of Omadacycline:

Omadacycline 相关抗体

Top Publications Citing Use of Products

    Omadacycline purchased from MCE. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Omadacycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

    查看 Antibiotic 亚型特异性产品:

    查看所有亚型
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].

    IC50 & Target

    Tetracycline

     

    体外研究
    (In Vitro)

    Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively[2].
    Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Omadacycline 相关抗体:
    体内研究
    (In Vivo)

    Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    556.65

    Formula

    C29H40N4O7
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    -20°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 125 mg/mL (224.56 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    Methanol 中的溶解度 : 125 mg/mL (224.56 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.7965 mL 8.9823 mL 17.9646 mL
    5 mM 0.3593 mL 1.7965 mL 3.5929 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Omadacycline 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / Methanol 1 mM 1.7965 mL 8.9823 mL 17.9646 mL 44.9115 mL
    5 mM 0.3593 mL 1.7965 mL 3.5929 mL 8.9823 mL
    10 mM 0.1796 mL 0.8982 mL 1.7965 mL 4.4912 mL
    15 mM 0.1198 mL 0.5988 mL 1.1976 mL 2.9941 mL
    20 mM 0.0898 mL 0.4491 mL 0.8982 mL 2.2456 mL
    25 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.7965 mL
    30 mM 0.0599 mL 0.2994 mL 0.5988 mL 1.4971 mL
    40 mM 0.0449 mL 0.2246 mL 0.4491 mL 1.1228 mL
    50 mM 0.0359 mL 0.1796 mL 0.3593 mL 0.8982 mL
    60 mM 0.0299 mL 0.1497 mL 0.2994 mL 0.7485 mL
    80 mM 0.0225 mL 0.1123 mL 0.2246 mL 0.5614 mL
    100 mM 0.0180 mL 0.0898 mL 0.1796 mL 0.4491 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Omadacycline389139-89-3PTK 0796 AmadacyclinePTK0796PTK-0796BacterialAntibiotictetracyclineantibacterialagentproteinsynthesisbroadspectrumGram-positiveGram-negativeanaerobicatypicalpathogensacutebacterialskinskin-structureinfectionscommunity-acquiredpneumoniaurinarytractInhibitorinhibitorinhibit

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    目录号：
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