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Palmitoyl serotonin  (Synonyms: PA-5HT)

目录号: HY-131678
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Palmitoyl serotonin (PA-5HT) 是一种以花生四烯酰血清素 (FAAH 拮抗剂) 为模式的混合分子。Palmitoyl serotonin 抑制 L-3,4-二羟基苯丙氨酸 (HY-N0304) 诱导的异常不自主运动。Palmitoyl serotonin 具有研究帕金森病 (PD)的潜力。

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Palmitoyl serotonin Chemical Structure

Palmitoyl serotonin Chemical Structure

CAS No. : 212707-51-2

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Palmitoyl serotonin 相关抗体

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生物活性

Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD)[1][2].

体内研究
(In Vivo)

Palmitoyl serotonin ( 0.3 mg/kg; daily for 10 days) 可有效减轻左旋多巴诱导的运动障碍 (LID) 的发展，并增加半侧帕金森病小鼠模型中 ERK1/2 磷酸化和 FosB/ΔFosB 表达[ 1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25-28 g, Eight-week-old male C57BL/6J mice ( 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian mouse model)[1]
Dosage: 0.3 mg/kg
Administration: daily for 10 days
Result: Reduced axial, limb, and locomotive AIM scores on day 10, suppressed the hyper-phosphorylation of ERK1/2 in the 6-OHDA-lesioned striatum, suppressed the overexpression of FosB and ΔFosB in the 6-OHDA-lesioned striatum.
分子量

414.62

Formula

C26H42N2O2
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Palmitoyl serotonin 相关分类

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Keywords:

Palmitoyl serotonin212707-51-2PA-5HTOthersdyskinesiaERK1/2 phosphorylationFosB/ΔFosBparkinson's diseaseInhibitorinhibitorinhibit

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