2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-L1-IN-3

PD-L1-IN-3 (Compound 4a) 是一种靶向 PD-1/PD-L1 的化合物，抑制 PD-L1 的 IC50 值为 4.97nM，对 Jurkat T 细胞的 EC50 值为 2.70 μM。PD-L1-IN- 3可以结合PD-L1 二聚体，阻止 PD-1 与 PD-L1 结合，从而阻断 PD-1 的信号传导。PD-L1-IN-3 可用于肺癌和黑色素瘤等疾病的研究。

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PD-L1-IN-3 Chemical Structure

PD-L1-IN-3 Chemical Structure

CAS No. : 2953044-29-4

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PD-L1-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research[1].

体外研究
(In Vitro)

PD-L1-IN-3 (Compound 4a) (0.01-100 μM, 40分钟) 破坏 PD-1 和 PD-L1 之间的结合，增强 TCR 介导的 Jurkat 细胞活化[1]。
PD-L1-IN-3 (0.01-100, 40分钟)在 PD-L1+ 在 H358 肿瘤中有较高的摄取，其摄取与 PD-L1 表达相关[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-L1-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 0.01-100 μM
Incubation Time: 40 min
Result: Observed EC50 value of 2.70 μM.

Immunofluorescence[1]

Cell Line: PD-L1+/− (H358 and ES2) tumor
Concentration: 0.01-100 μM
Incubation Time: 40 min
Result: Observed 40-55% higher uptake in PD-L1+ H358 tumors than in wild-type counterparts.
Failed to discriminate between wild-type and knock-out for ES2 slides.
体内研究
(In Vivo)
Animal Model: PD-L1+/− (H358 and ES2) tumor[1]
Dosage: 0.01-100 μM
Administration: incubation
Result: Observed 40-55% higher uptake in PD-L1+ H358 tumors than in wild-type counterparts.
Failed to discriminate between wild-type and knock-out for ES2 slides.
分子量

374.86

Formula

C19H16ClFN2OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-L1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1-IN-32953044-29-4PD-1/PD-L1PD-1/Programmed death-ligand 1small molecularlung cancerInhibitorinhibitorinhibit

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