2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-L1-IN-4

PD-L1-IN-4 (Compound X18) 是一种具有口服活性的 PD-L1 抑制剂，对 PD-1/PD-L1 相互作用表现出显著的抑制活性 (IC50 = 1.3 nM)，并增强 PD-L1 对 T 细胞的抑制作用 (EC50 = 152.8 nM)。PD-L1-IN-4可用于癌症的研究。

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PD-L1-IN-4 Chemical Structure

PD-L1-IN-4 Chemical Structure

CAS No. : 2597056-86-3

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PD-L1-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer[1].

体外研究
(In Vitro)

PD-L1-IN-4 (0.1-10 μM，24 h) 可减轻 PD-L1 的免疫抑制作用，并减少 PD-L1/aAPC/CHO-K1 细胞中细胞表面可接近的 PD-L1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-L1-IN-4 相关抗体:
体内研究
(In Vivo)


药代动力学分析[1]

Route Dose (mg/kg) t1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng·h/mL)
p.o. 50 5.3 0.1 45.6 82.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

735.20

Formula

C38H40ClFN4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-L1-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-L1-IN-42597056-86-3PD-1/PD-L1PD-1/Programmed death-ligand 1T cellsPD-L1aAPCCHO-K1SDInhibitorinhibitorinhibit

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产品名称：
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目录号：
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