2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Pentabromopseudilin

Pentabromopseudilin (PBrP) 是一种海洋抗生素，从海洋细菌 Pseudomonas bromoutilis 和 Alteromonas luteoviolaceus 中分离出来。 PBrP 具有抗菌、抗肿瘤和植物毒性活性。PBrP 是肌球蛋白 Va (MyoVa) 的可逆变构抑制剂。PBrP 还是转化生长因子-β (TGF-β) 活性的有效抑制剂。PBrP 可用于纤维化疾病和癌症的研究。

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Pentabromopseudilin Chemical Structure

Pentabromopseudilin Chemical Structure

CAS No. : 10245-81-5

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Pentabromopseudilin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].
体外研究
(In Vitro)

Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) 可防止 TGF-β 诱导的 Smad 蛋白磷酸化和核转位[1]。
PBrP (0.5 μM, 6 h) 抑制 TGF-β 刺激的转录反应[1]。
PBrP (0-1 μM, 6 h) 抑制 A549 细胞中 TGF-β 诱导的 EMT[1]。
PBrP (0.2 μM, 20 h) 抑制 TGF-β 诱导的细胞迁移[1]。
PBrP (0.01-1⟩μM, 6 h) 通过增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。
PBrP (0.5μM, 0, 1, 3 h) 通过细胞膜穴样内陷增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pentabromopseudilin 相关抗体:

Western Blot Analysis[1]

Cell Line: Mv1Lu, A549, Clone 9 and HepG2 cells
Concentration: 0.01-1 μM (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5 μM (Mv1Lu, A549 and HepG2 cells)
Incubation Time: 6 h (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5, 1, 2, 4, 6 h (Mv1Lu, A549 and HepG2 cells)
Result: Suppressed the TGF-β-stimulated Smad2/3 phosphorylation in a dose-dependent manner in these cell lines.
Prevented TGF-β induced the nuclear translocation of Smad2/3 and PBrP alone did not alter the localisation of Smad proteins.

Immunofluorescence[1]

Cell Line: A549 cells
Concentration: 0.2 μM
Incubation Time: 6 h
Result: Abolished TGF-β-induced Smad2/3 nuclear translocation.

Cell Migration Assay [1]

Cell Line: A549 cells
Concentration: 0.2 μM
Incubation Time: 20 h
Result: Suppressed TGF-β-stimulated cell migration and did not close the wound.
分子量

553.66

Formula

C10H4Br5NO
CAS 号
结构分类
初始来源

Pseudomonas bromoutilis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pentabromopseudilin 相关分类

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Keywords:

Pentabromopseudilin10245-81-5TGF-β ReceptorTransforming growth factor beta receptorsantibioticPseudomonas bromoutilisAlteromonas luteoviolaceusantimicrobialanti-tumourphytotoxicMyoVaTGF-βfibrotic diseasescancerInhibitorinhibitorinhibit

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