Pep2m, myristoylated  (Synonyms: Myr-Pep2m)

Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)^[1][2].

NSF/GluR2 interactions^[1]

Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation^[1].
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis^[1].
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pep2m, myristoylated (10 µg/20 µL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1383.81

C₆₃H₁₁₈N₁₈O₁₄S

1423381-07-0

{Myr}-KRMKVAKNAQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827.  [Content Brief]

  [2]. Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582.  [Content Brief]