2. NF-κB MAPK/ERK Pathway JAK/STAT Signaling Stem Cell/Wnt
  3. IKK JNK STAT p38 MAPK ERK
  4. Peramivir

Peramivir  (Synonyms: 帕拉米韦; RWJ-270201; BCX-1812)

目录号: HY-17015A 纯度: 98.19%
COA 产品使用指南

摩尔计算器

Peramivir 是一种的新型环戊烷神经氨酸酶 (novel cyclopentane neuraminidase) 流感病毒抑制剂。Peramivir 具有抗病毒活性和抗细胞因子作用，可用于新型冠状病毒肺炎的研究。

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Peramivir Chemical Structure

Peramivir Chemical Structure

CAS No. : 330600-85-6

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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10 mg ￥1040
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25 mg ￥2000
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50 mg ￥3200
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100 mg ￥4480
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Customer Review

Other Forms of Peramivir:

Peramivir 相关抗体

Top Publications Citing Use of Products

查看 IKK 亚型特异性产品:

查看所有亚型
IKK-α IKK-β IKK IKKε TBK1

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19[1][2][3].

IC50 & Target

IKK-α

 

STAT3

 

ERK1

 

ERK2

 

体外研究
(In Vitro)

Peramivir (0.3125-40 μM, 4 h) 对巨噬细胞无毒性[1]。
Peramivir (2-10 μM, 6-12 h) 抑制 LPS 诱导的 hPBMCs 细胞因子释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Peramivir 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: RAW 264.7
Concentration: 0.3125 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 4 h
Result: Showed no apparent toxicity in the peramivir-treated macrophages at concentrations up to 40 μM.
体内研究
(In Vivo)

Peramivir (20-60 mg/kg，腹腔注射，单次剂量) 可抑制 LPS 诱导的细胞因子风暴，减轻急性肺损伤，延长细胞因子风暴综合征模型小鼠的生存时间[1]。
Peramivir (75 mg/kg，肌肉注射，每天 1 次，连续 7 天) 在 B 型流感病毒感染的免疫抑制小鼠模型中拯救了 BR/08 致死性攻击的 BALB scid 小鼠[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cytokine storm syndrome model mice [1]
Dosage: 20 mg/kg, 60 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Decreased 8 cytokines including TNF-a, IFN-a, IFN-γ, chemokines (MCP-1), GM-CSF, IL-1β, IL-6 and IL-12.
Showed less inflammatory cell infiltrations, mild alveolar thickening and less bleeding points or congestion.
Showed significant protective effects to the lung tissues.
Animal Model: Immunocompromised murine models of infuenza B virus infection[2]
Dosage: 75 mg/kg
Administration: Intramuscular injection (i.m.)
Result: Conferred complete protection against lethality, whether it was administered in one (1×), two (2×), or four (4×) doses, with maximum mean weight loss of 10% to 14%.
Resulted in a trend of decreasing virus replication in the nasal cavities and lungs.
Reduced the virus titers and replication.
Clinical Trial
分子量

328.41

Formula

C15H28N4O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

帕拉米韦
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Peramivir 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peramivir330600-85-6RWJ-270201 BCX-1812帕拉米韦RWJ270201RWJ 270201BCX1812BCX 1812BCX-1812IKKJNKSTATp38 MAPKERKIκB kinaseI kappa B kinase c-Jun N-terminal kinaseExtracellular signal regulated kinasesMacrophagehPBMCcytokine storm syndrome model miceimmunocompromised murine models of infuenza B virus infectionCOVID-19Inhibitorinhibitorinhibit

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目录号：
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