2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K-IN-37

PI3K-IN-37 (Example 84.1) 是一种 PI3K α/β/δ 抑制剂，其 IC50 分别为 6、8、4 nM。PI3K-IN-37 可抑制mTOR (IC50=4 nM)。

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PI3K-IN-37 Chemical Structure

PI3K-IN-37 Chemical Structure

CAS No. : 1257547-40-2

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PI3K-IN-37 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM)[1].

IC50 & Target[1]

PI3Kδ

4 nM (IC50)

mTOR

4 nM (IC50)

PI3Kα

6 nM (IC50)

PI3Kβ

8 nM (IC50)

体外研究
(In Vitro)

PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1].
PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-37 相关抗体:

Cell Viability Assay[1]

Cell Line: Rat1 cells
Concentration: 0.005-10 μM
Incubation Time: 30 min
Result: Inhibited Pl3-kinase isoforms alpha, beta or delta phosphorylation with the IC50s of <5 nM, 8 nM, and 18 nM, respectively.

Cell Viability Assay[1]

Cell Line: TSC1-/- MEF cells
Concentration: 0.005-1 μM
Incubation Time: 60 min
Result: Inhibited S6 Ribosomal Protein phosphorylation (IC50=2 nM).
分子量

442.51

Formula

C25H26N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K-IN-37 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-371257547-40-2PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinRat1TSC1-/- MEFInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147284
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