2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-12

PI3K/mTOR Inhibitor-12 是一种口服有效的选择性 PI3K/mTOR 抑制剂，对 PI3Kα 和 mTOR 的 IC50 值分别为 0.06 nM 和 3.12 nM。PI3K/mTOR Inhibitor-12 具有抗肿瘤活性。PI3K/mTOR Inhibitor-12 具有较低的肝毒性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PI3K/mTOR Inhibitor-12 Chemical Structure

PI3K/mTOR Inhibitor-12 Chemical Structure

CAS No. : 2891692-83-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PI3K/mTOR Inhibitor-12 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/mTOR Inhibitor-12 is a potent, orally active and selective PI3K/mTOR inhibitor with IC50 values of 0.06 nM and 3.12 nM for PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-12 has antitumor activity. PI3K/mTOR Inhibitor-12 has lower liver toxicity[1].

IC50 & Target[1]

PI3Kα

0.06 nM (IC50)

mTOR

3.12 nM (IC50)

体外研究
(In Vitro)

PI3K/mTOR Inhibitor-12 (compound 48; 72 h) inhibits cancer cells growth with IC50 values of 0.07, 0.09, 0.54, 0.54, and 0.68 μM for PC-3, HT-29,HCT116, LOVO, and HUVEC cells, respectively[1].
PI3K/mTOR Inhibitor-12 (0.25-1 μM; 12-48 h; HCT116 and HT-29 cells) inhibits the activation of PI3K and mTOR in the cellular context[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/mTOR Inhibitor-12 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT116 and HT-29 cells
Concentration: 0.25, 0.5, and 1 μM
Incubation Time: 12, 24, and 48 hours
Result: Inhibited the expression levels of AKT, p70S6K and their phosphorylated forms in a dose- and time-dependent manner.
体内研究
(In Vivo)

PI3K/mTOR Inhibitor-12 (compound 48; 20 mg/kg; p.o.; daily, for 14 d) inhibits tumor growth of HCT116 xenografts in female BALB/c nude mice[1].
PI3K/mTOR Inhibitor-12 (1 and 5 mg/kg; i.v. and p.o.; male SD rats) has fast plasma clearance (1428 mL/h/kg) and short T1/2 (2.33 h) and the AUC0-∞ is 1356 h*ng/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 xenografts in female BALB/c nude mice[1]
Dosage: 20 mg/kg
Administration: Oral administration, daily, for 14 days
Result: Reduced the growth of HCT116 tumors, and the tumor growth inhibition (TGI) was 73.33%.
Had lower liver toxicity of HCT116 xenografts in female BALB/c nude mice.
Animal Model: Male SD rats[1]
Dosage: 1 and 5 mg/kg
Administration: Intravenous injection (1 mg/kg) and oral administration (5 mg/kg)
Result: 1.19
Parameter I.V. (1 mg/kg) Parameter P.O. (5 mg/kg)
T1/2 (h) 0.6 T1/2 (h) 2.33
CL (mL/h/kg) 1428 Cmax (ng/mL) 1218
Vdss (mL/Kg) 528 AUC0-∞ (h*ng/mL) 1356
AUC0-∞ (h*ng/mL) 760 F% 33.1
分子量

611.62

Formula

C27H27F2N9O4S
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/mTOR Inhibitor-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-122891692-83-2PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinanticancerliver toxicityHCT116HT-29phosphorylationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PI3K/mTOR Inhibitor-12
目录号：
HY-152238
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z