2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase
  4. Pinealon

Pinealon 是一种由 3 个氨基酸组成的肽，具有神经保护特性。Pinealon 可防止活性氧 (ROS) 积累并抑制 ERK 1/2 的激活。Pinealon 可以刺激脑组织主要细胞成分的功能活动，减少自发性细胞死亡。Pinealon 保护大鼠后代免受产前高同型半胱氨酸血症。

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Custom Peptide Synthesis

Pinealon Chemical Structure

Pinealon Chemical Structure

CAS No. : 175175-23-2

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Pinealon 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].

体外研究
(In Vitro)

Pinealon (10, 50, 100 nM; 30 min) 以剂量依赖性方式阻止哇巴因诱导的小脑颗粒细胞中 ROS 积累的增加[1]。
Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) 抑制暴露于 500 mM 同型半胱氨酸 (HC) 的大鼠小脑颗粒细胞中 ERK 1/2 的激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pinealon 相关抗体:
体内研究
(In Vivo)

Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) 对维持大鼠先前获得的技能显示出剂量依赖性作用[2]。
Pinealon (10 µg/kg; daily for 5 days) 保护大鼠后代免受产前高同型半胱氨酸血症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-250 g, white male rats[2]
Dosage: 50, 100, 200 ng/kg
Administration: Injection; for 5 days
Result: Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze.
Animal Model: 180-200 g, Female Wistar rats[3]
Dosage: 10 µg/kg
Administration: I.p.; daily for 5 days
Result: Protected the rat offspring from prenatal hyperhomocysteinemia.
分子量

418.40

Formula

C15H26N6O8
CAS 号
Unlabeled CAS

Sequence Shortening

EDR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pinealon 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinealon175175-23-2ROS KinaseInhibitorinhibitorinhibit

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