2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. PNU-177864

PNU-177864 是一种有效的，选择性的，口服活性的多巴胺 D3 受体拮抗剂。PNU-177864 在结构上与阳离子两亲活性分子一致，可在体内诱导磷脂代谢，并具有抗精神分裂症活性。

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PNU-177864 Chemical Structure

PNU-177864 Chemical Structure

CAS No. : 250266-51-4

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规格 价格 是否有货 数量
1 mg ￥1650
In-stock
5 mg ￥3320
In-stock
10 mg ￥4650
In-stock
25 mg ￥7400
In-stock
50 mg ￥9950
In-stock
100 mg   询价  
200 mg   询价  

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Customer Review

Other Forms of PNU-177864:

PNU-177864 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PNU-177864 is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 is structurally consistent with a cationic amphiphilic agent (CAD) and induces phospholipidosis in vivo. PNU-177864 antischizophrenic activity[1][2].

体内研究
(In Vivo)

PNU-177864 (12.5-200 mg/kg；口服；每天；持续 2-4 周；Sprague-Dawley 大鼠) 治疗在狗或大鼠的异常靶器官 (包括附睾、垂体和毛囊) 中诱导磷脂沉积[ 1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Sprague-Dawley rats (8-9-week-old)[1]
Dosage: 12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks)
Administration: Oral gavage; daily; for 2-4 weeks
Result: Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
分子量

402.43

Formula

C18H21F3N2O3S
CAS 号
Unlabeled CAS

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

PNU-177864 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU-177864250266-51-4PNU177864PNU 177864Dopamine ReceptorD3-receptorcationicamphiphilicphospholipidosisCADantischizophrenicmyopathyInhibitorinhibitorinhibit

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产品名称：
PNU-177864
目录号：
HY-103406
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