2. Cell Cycle/DNA Damage
  3. Wee1
  4. Pomalidomide-C3-adavosertib

Pomalidomide-C3-adavosertib 

目录号: HY-133618 纯度: 99.84%
COA 产品使用指南

摩尔计算器

Pomalidomide-C3-adavosertib 是一种快速和选择性的 Wee1 降解剂 (IC50=3.58 nM)。Pomalidomide-C3-adavosertib 具有抗癌细胞增殖活性，并能诱导细胞凋亡。

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Pomalidomide-C3-adavosertib Chemical Structure

Pomalidomide-C3-adavosertib Chemical Structure

CAS No. : 2414418-49-6

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规格 价格 是否有货 数量
1 mg ￥2300
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5 mg ￥5600
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10 mg ￥7700
In-stock
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Pomalidomide-C3-adavosertib 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pomalidomide-C3-adavosertib is a rapid and selective Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis[1].

体外研究
(In Vitro)

Pomalidomide-C3-adavosertib (1 nM-10 μM; 24, 48, and 72 h) induces CRBN-dependent anti-proliferative effects and synergized with Olaparib[1].
Pomalidomide-C3-adavosertib (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint[1].
Pomalidomide-C3-adavosertib (1 nM-10 μM; 6 h) degrades Wee1 in MOLT4 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-C3-adavosertib 相关抗体:

Cell Proliferation Assay[1]

Cell Line: OVCAR8, COV362, and Kuramochi cells
Concentration: 1 nM-10 μM
Incubation Time: 24, 48, and 72 hours
Result: Degraded Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.

Cell Cycle Analysis[1]

Cell Line: MOLT4 cells
Concentration: 100 nM
Incubation Time: 24 hours
Result: Led to reduced pCDKl Y15, increased apoptosis, and increased unrepaired DNA.

Western Blot Analysis[1]

Cell Line: MOLT4 cells
Concentration: 1 nM-10 μM
Incubation Time: 6 hours
Result: Degraded Wee1 after a 6-hour treatment in MOLT4 cells, and induced the downstream changes expected from Wee1 loss-including a decrease in phosphorylated cyclin-dependent kinase 1 (pCDK1) and an increase in pH 3.
分子量

799.88

Formula

C42H45N11O6
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Pomalidomide-C3-adavosertib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C3-adavosertib2414418-49-6Wee1anti-proliferation activityinduce apoptosisMOLT4OVCAR8COV362KuramochiInhibitorinhibitorinhibit

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