2. Inhibitory Antibodies
  3. Prezalumab

Prezalumab  (Synonyms: AMG 557)

目录号: HY-P99414 纯度: 99.23%
COA

摩尔计算器

Prezalumab (AMG 557) 是一种靶向 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 对系统性红斑狼疮关节炎有研究作用。Prezalumab 可用于干燥综合征皮肤红斑狼疮、银屑病和系统性红斑狼疮 (SLE) 的研究。

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Prezalumab Chemical Structure

Prezalumab Chemical Structure

CAS No. : 1523164-68-2

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规格 价格 是否有货 数量
1 mg ￥3000
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5 mg ￥7800
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Prezalumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1].

同型

Human IgG2 kappa
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models[1].
Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition[1].
1.19 Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys[1].

Cynomolgus Monkeys
IV 10 mg/kg		 Cynomolgus Monkeys
SC 10 mg/kg
Cmax (μg/mL) 264 112
Tmax (hr) 72
AUC0-inf (μg•hr/mL) 26100 23800
MRT0-inf (hr) 138 144
CL (mL/hr/kg) 0.388 0.427
Vss (mL/kg) 52.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
Unlabeled Cas

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.23%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Prezalumab 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prezalumab1523164-68-2AMG 557AMG557AMG-557Othersmonoclonal antibodySLEpsoriasiscynomolgus monkeysCIAmiceInhibitorinhibitorinhibit

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