1. Anti-infection Membrane Transporter/Ion Channel Autophagy
  2. Bacterial Potassium Channel Autophagy
  3. Proflavine hemisulfate

Proflavine hemisulfate  (Synonyms: 硫酸原黄素; Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate)

目录号: HY-B0883 纯度: 98.45%
COA 产品使用指南

Proflavine hemisulfate 是一种吖啶染料,也是一种 DNA嵌入剂。可用作抗菌剂 (Anti-microbial)。Proflavine hemisulfate 可作为 Kir3.2 孔阻滞剂。Proflavine hemisulfate 可用于研究与 Kir3.2 相关的神经系统疾病。

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Proflavine hemisulfate Chemical Structure

Proflavine hemisulfate Chemical Structure

CAS No. : 1811-28-5

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases[2].

体外研究
(In Vitro)

Proflavine (0.1-10 μM; 24 hours) inhibits the growth of Kir3.2-transformant cells and Kir3.2 activity in a concentration-dependent manner[1].
Proflavine (300 μM) progressively reduces the current amplitude of Kir3.2 mutant to 27.7±4.3% of the control[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Kir3.2*-transformant BYT123 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 24 hours
Result: Dose-dependent inhibition of the growth of Kir3.2*-transformant cells.
Attenuated the growth of Kir3.2*-transformant cells without affecting the growth of control cells.
体内研究
(In Vivo)

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (weighing approximately 200 g)[3]
Dosage: 20 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result: Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.
Clinical Trial
分子量

258.28

Formula

C13H11N3.1/2H2SO4

CAS 号
性状

固体

颜色

Pink to red

中文名称

硫酸原黄素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 5 mg/mL (19.36 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8718 mL 19.3588 mL 38.7177 mL
5 mM 0.7744 mL 3.8718 mL 7.7435 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8718 mL 19.3588 mL 38.7177 mL 96.7942 mL
5 mM 0.7744 mL 3.8718 mL 7.7435 mL 19.3588 mL
10 mM 0.3872 mL 1.9359 mL 3.8718 mL 9.6794 mL
15 mM 0.2581 mL 1.2906 mL 2.5812 mL 6.4529 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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