2. MAPK/ERK Pathway PROTAC
  3. MAP4K PROTACs
  4. PROTAC HPK1 Degrader-1

PROTAC HPK1 Degrader-1 (Compound B1) 是一种有效的 HPK1 降解剂，DC50 值为 1.8 nM。PROTAC HPK1 Degrader-1 抑制 SLP76 蛋白的磷酸化，IC50 值为 496.1 nM。PROTAC HPK1 Degrader-1 是一种真正的 HPK1-PROTAC 降解剂，为进一步研究 TCR 信号转导中的 HPK1 提供了潜在的工具。

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PROTAC HPK1 Degrader-1 Chemical Structure

PROTAC HPK1 Degrader-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PROTAC HPK1 Degrader-1 相关抗体

Top Publications Citing Use of Products

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling[1].

分子量

785.84

Formula

C43H43N7O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC HPK1 Degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HPK1 Degrader-1MAP4KPROTACsMAPK Kinase Kinase KinasePROTACTCRSLP76phosphorylationInhibitorinhibitorinhibit

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HY-163372
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