IL-17D  (白细胞介素-17D)

Interleukin-17D (IL-17D) 属于 IL-17 细胞因子家族。IL-17D 在纤维肉瘤肿瘤细胞中高度分泌^[1]。IL-17D 在骨骼肌、脑、脂肪组织、心脏、肺和胰腺中高表达，而在骨髓、胎儿肝脏、肾脏、白细胞、肝脏、淋巴结、胎盘、脾脏、胸腺和扁桃体中低表达^[2]。IL-17D 刺激 IL-6、IL-8 和 GM-CSF 的产生。IL-17D 也诱导骨髓生长因子和趋化因子。IL-17D 刺激白细胞局部浸润和增殖^[2]。IL-17D 通过调节 CD8 T 细胞调节细胞内细菌和病毒感染期间的保护性免疫。IL-17D 在自身免疫性疾病中发挥多种作用，是肿瘤免疫治疗的潜在靶点^[2]。

Interleukin-17D (IL-17D) belongs to the IL-17 cytokine family. IL-17D is highly secreted by fibrosarcoma tumor cells^[1]. IL-17D is highly expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas, while it is expressed at low levels in bone marrow, fetal liver, kidney, leukocytes, liver, lymph nodes, placenta, spleen, thymus, and tonsils^[2]. IL-17D stimulates the production of IL-6, IL-8, and GM-CSF. IL-17D also induces myeloid growth factors and chemokines. IL-17D stimulates local infiltration and proliferation of leukocytes^[2]. IL-17D regulates protective immunity during intracellular bacteria and virus infection via regulating CD8 T cells^[1]. IL-17D plays multiple roles in autoimmune disease and is a potential target for tumor immunotherapy^[2].

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