2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-17 Receptor
  6. IL-17RB

IL-17RB  (白介素-17 受体 B)

重组蛋白定制服务

IL-17RB (白细胞介素 17 受体 B)，一种 47.9 kDa 的跨膜蛋白 (462 aa)，属于 IL-17 受体家族，可被 IL-17B 激活，与炎症性疾病和癌症有关。IL-17RB在各种内分泌组织和不同器官如肾、肝和黏膜组织的上皮细胞中表达[1][2][3] .
IL-17RB 具有一个 SEFIR 细胞质结构域，涉及同型二聚化和信号蛋白的募集 (与 IL-17RA 共享) 和一个 TRAF6 结合结构域 (在 IL-17RA 中未发现)。 IL-17B 与结合异二聚体 IL-17RA/IL-17RB 复合物的 IL-17E (也称为 IL-25) 共享其受体 IL-17RB。IL-17B 对 IL-17RB 的结合亲和力比 IL-17E 低。它不结合 IL-17、IL-17C 和 IL-17F。配体结合后，IL-17RB 激活经典的 NK-κB 通路以及 ERK、JNK 和 p38。据报道，IL-17RB 在胃癌组织中的表达显着增加。此外，IL-17RB 的过表达与转移密切相关，并且与胰腺癌的无进展生存期呈负相关。IL-17RB 可通过 ERK1/2 通路介导的 MMP-9 表达增强甲状腺癌细胞侵袭转移[1]。IL-17RB 在人先天 2 型淋巴细胞、自然杀伤 T (NKT) 细胞和 Th2 细胞中的表达表明其在免疫细胞中的潜在作用[3]。

IL-17RB (Interleukin 17 receptor B), a 47.9 kDa transmembrane protein (462 aa) that belongs to the IL-17 receptor family, and can be activated by IL-17B. It has been proved to be involved in inflammatory diseases and cancers. IL-17RB is expressed in various endocrine tissues and in epithelial cells in different organs such as kidney and liver and mucosal tissues[1][2][3].
IL-17RB has a SEFIR cytoplasmic domain implicated in homotypic dimerization and recruitment of signaling proteins (shared with IL-17RA) and a TRAF6-binding domain (not found in IL-17RA). IL-17B shares its receptor IL-17RB with IL-17E (also known as IL-25) that binds to the heterodimeric IL-17RA/IL-17RB complex. The binding affinity (KD) of IL-17B for IL-17RB is around 30-fold lower than that of IL-17E. It does not bind IL-17, IL-17C and IL-17F. Upon ligand binding, IL-17RB activates the canonical NK-κB pathway as well as ERK, JNK, and p38. It is reported that IL-17RB expression is significantly increased in gastric cancer tissues. Moreover, overexpression of IL-17RB is strongly associated with metastasis and inversely correlates with progression-free survival in pancreatic cancer. IL-17RB can enhance thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression[1]. IL-17RB expression in human innate type 2 lymphocytes, natural killer T (NKT) cells, and Th2 cells suggests a potential role in immune cells[3].

目录号 产品名 / 同用名 种属 表达系统
目录号 产品名 作用方式 纯度
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z