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细胞侵袭

细胞侵袭指细胞穿越组织或细胞间的基底膜和间质,参与生理过程如细胞迁移、组织发育及肿瘤转移。该过程涉及蛋白酶解、胞外基质附着和细胞运动等。细胞侵袭的研究常借助Transwell实验、Boyden室和基底膜模型等技术,以评估细胞侵袭能力,并有助于揭示疾病发展及治疗策略。


Cell invasion refers to cells crossing the basement membrane and stroma between tissues or cells and participating in physiological processes such as cell migration, tissue development and tumor metastasis. This process involves proteolysis, extracellular matrix attachment, and cell movement. Research on cell invasion often uses techniques such as Transwell assay, Boyden chamber and basement membrane model to evaluate cell invasion ability and help reveal disease development and treatment strategies.

相关实验方案

  • 细胞侵袭(cell invasion)是指细胞通过细胞外基质从一个区域迁移到另一个区域的能力。细胞侵袭是正常细胞和癌细胞应对化学和机械刺激的反应。在迁移到新区域之前,细胞外基质被细胞内的蛋白酶降解。细胞侵袭常发生于伤口修复、血管形成和炎症反应以及组织的异常浸润、肿瘤细胞转移等过程中。