2. Immunology/Inflammation
  3. PSMA
  4. PSMA-IN-2

PSMA-IN-2 是 PSMA 的抑制剂，其 Ki 值为 1.07 nM。PSMA-IN-2 PSMA-IN-2显示出良好的in vivo近红外成像 (λEM = 1088 nm, λex = 808 nm)，可用于PSMA阳性肿瘤小鼠的近红外II成像引导的肿瘤切除手术。

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PSMA-IN-2 Chemical Structure

PSMA-IN-2 Chemical Structure

CAS No. : 2946600-14-0

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PSMA-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSMA-IN-2 is an inhibitor of PSMA with a Ki value of 1.07 nM. PSMA-IN-2 displays favorable in vivo NIR imaging (λEM = 1088 nm, λex = 808 nm), and can be used for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice[1].

IC50 & Target

PSMA

1.07 nM (Ki)

体内研究
(In Vivo)

PSMA-IN-2 (compound 24) (0.85 mg/kg, i.v., 24 h)is confirmed by NIR-II imaging to bind specifically to PSMA in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 22Rv1 xenograft models[1]
Dosage: 0.85 mg/kg
Administration: Intravenous injection (i.v.)
Result: Excreted from the blood pool, increasing signal intensity was observed in 22Rv1 xenograft over time as, the background signal became gradually weak, under 808 nm laser irradiation (1100 nm long-pass filter, 400 ms). Inhibition ranged from 38% to 52%, based on semi-quantitative data DCFPyL in tumors.
分子量

1257.27

Formula

C54H60N14O18S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSMA-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-IN-22946600-14-0PSMAProstate-specific membrane antigen22Rv1selectivexenograftprostate cancerNIR imagingFluorescent DyeInhibitorinhibitorinhibit

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产品名称：
PSMA-IN-2
目录号：
HY-149298
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