1. Anti-infection Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis
  2. Parasite Potassium Channel Cytochrome P450 Apoptosis
  3. Quinidine gluconic acid

Quinidine gluconic acid  (Synonyms: 奎尼丁葡萄糖酸)

目录号: HY-B1751F
产品使用指南

Quinate 是一种抗心律失常剂。Quinate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也是 K+ 通道 (K+ channel) 的有效阻断剂,其 IC50 值为 19.9 μM,也可诱导凋亡。Quinate 也可用作疟疾的研究。

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Quinidine gluconic acid Chemical Structure

Quinidine gluconic acid Chemical Structure

CAS No. : 7054-25-3

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Quinidine gluconic acid 的其他形式现货产品:

Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research[1][2][3][4].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Quinate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
体内研究
(In Vivo)

Quinate shows effects on the PTZ-induced seizure threshold[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
分子量

520.57

Formula

C26H36N2O9

CAS 号
中文名称

奎尼丁葡萄糖酸;异奎宁葡萄糖酸;奎尼定葡萄糖酸;喹啉丁葡萄糖酸;奎纳定葡萄糖酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Quinidine gluconic acid
目录号:
HY-B1751F
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