Animal-Free IL-26/AK155 蛋白, Human (His)

The IL-26/AK155 Monomer protein potentially plays a crucial role in mucosal immunity, with a pro-inflammatory function linked to inflammatory bowel disease. Functionally, it activates various signaling pathways, induces the expression of immune mediators, and decreases intestinal epithelial cell proliferation. Its oligomeric state, forming homodimers, emphasizes its significance in mediating cellular responses and signaling cascades within mucosal immunity. Animal-Free IL-26/AK155 Protein, Human (His) is the recombinant human-derived animal-FreeIL-26/AK155 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-26/AK155 Protein, Human (His) is 150 a.a., with molecular weight of ~18.53 kDa.

IL-26/AK155 单体蛋白可能在粘膜免疫的局部机制中发挥关键作用，表明其参与粘膜组织内复杂的免疫调节过程。它似乎具有促炎功能，可能与炎症性肠病有关，强调了它在胃肠道炎症过程中的重要性。从功能上讲，IL-26/AK155 单体可激活各种信号通路，包括 STAT1 和 STAT3、MAPK1/3 (ERK1/2)、JUN 和 AKT，表明对细胞反应具有广泛影响。它诱导 SOCS3、TNF-α 和 IL-8 的表达，以及 IL-8 和 IL-10 的分泌，以及 ICAM1 的表面表达，强调其参与免疫和炎症介质的调节。此外，IL-26/AK155 Monomer 具有降低肠上皮细胞增殖的能力。值得注意的是，它的活性受到肝素的抑制，增加了一层监管控制。结构排列涉及同源二聚体的形成，强调其寡聚状态在介导粘膜免疫背景下的细胞反应和信号级联中的重要性。

Measure by its ability to induce IL-10 secretion in COLO205 cells. The ED₅₀ for this effect is <150 ng/mL

Human

E. coli

C-His

Q9NPH9 (K22-Q171)

55801  [NCBI]

MKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ

Approximately 18.53 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.